Check out the lab’s recent publication in Cancer Cell titled “Genome-wide CRISPR screens of T cell exhaustion identify chromatin remodeling factors that limit T cell persistence”! The journal cover depicts an artistic representation of our teams exciting CRISPR-based genome engineering work. You can see hands manipulating the human genome – meant to show the removal of Arid1a from the canonical BAF chromatin remodeling complex. Check out the feature here.
Check out Rafi Ahmed and Haydn Kissick’s preview on the research here.
This project has provided inspiration for a future where T cells may be engineered to be resistant to exhaustion. Well done team!