Tracking the immune response with single-cell genomics
Yost KE, Chang HY, Satpathy AT.
Vaccine, 16 December 2019
c-Jun overexpression in CAR T cells induces exhaustion resistance
Lynn RC, Weber EW, Gennert D, Sotillo E, Xu P, Good Z, Anbunathan H, Jones R, Tieu V, Granja J, DeBourcy C, Majzner R, Satpathy AT, Quake SR, Chang HY, Mackall CL.
Nature, 4 December 2019
GWAS for systemic sclerosis identifies multiple risk loci and highlights fibrotic and vasculopathy pathways
López-Isac E, Acosta-Herrera M, Kerick M, Assassi S, Satpathy AT, Granja J, Mumbach MR, Beretta L, Simeón CP, Carreira P, Ortego-Centeno N, Castellvi I, Bossini-Castillo L, Carmona FD, Orozco G, Hunzelmann N, Distler JHW, Franke A, Lunardi C, Moroncini G, Gabrielli A, de Vries-Bouwstra J, Wijmenga C, Koeleman BPC, Nordin A, Padyukov L, Hoffmann-Vold AM, Lie B; European Scleroderma Group†, Proudman S, Stevens W, Nikpour M; Australian Scleroderma Interest Group (ASIG), Vyse T, Herrick AL, Worthington J, Denton CP, Allanore Y, Brown MA, Radstake TRDJ, Fonseca C, Chang HY, Mayes MD, Martin J.
Nature Communications, 31 October 2019
An Nfil3-Zeb2-Id2 pathway imposes Irf8 enhancer switching during cDC1 development
Bagadia P, Huang X, Liu TT, Durai V, Grajales-Reyes GE, Nitschké M, Modrusan Z, Granja JM, Satpathy AT, Briseño CG, Gargaro M, Iwata A, Kim S, Chang HY, Shaw AS, Murphy TL, Murphy KM.
Nature Immunology, 1 September 2019
Cryptic activation of an Irf8 enhancer governs cDC1 fate specification
Durai V, Bagadia P, Granja JM, Satpathy AT, Kulkarni DH, Davidson JT 4th, Wu R, Patel SJ, Iwata A, Liu TT, Huang X, Briseño CG, Grajales-Reyes GE, Wöhner M, Tagoh H, Kee BL, Newberry RD, Busslinger M, Chang HY, Murphy TL, Murphy KM.
Nature Immunology,
Massively parallel single-cell chromatin landscapes of human immune cell development and intratumoral T cell exhaustion
Satpathy AT*, Granja JM*, Yost KE, Qi Y, Meschi F, McDermott GP, Olsen BN, Mumbach MR, Pierce SE, Corces MR, Shah P, Bell JC, Jhutty D, Nemec CM, Wang J, Wang L, Yin Y, Giresi PG, Chang ALS, Zheng GXY*, Greenleaf WJ*, Chang HY*. *contributed equally
Nature Biotechnology, 2 August 2019
Clonal replacement of tumor-specific T cells following PD-1 blockade
Yost KE*, Satpathy AT*, Wells DK, Qi Y, Wang C, Kageyama R, McNamara K, Granja JM, Sarin KY, Brown RA, Gupta RK, Curtis C, Bucktrout SL, Davis MM, Chang ALS*, Chang HY*. *contributed equally
Nature Medicine, 29 July 2019
HiChIRP reveals RNA-associated chromosome conformation
Mumbach MR*, Granja JG*, Flynn RA, Roake CM, Satpathy AT, Rubin AJ, Qi Y, Jiang Z, Shams S, Louie BH, Guo JK, Gennert DG, Corces MR, Khavari PA, Atianand MK, Artandi SE, Fitzgerald KA, Greenleaf WJ*, Chang HY*.
Nature Methods, 27 May 2019
A Subset of Type I Conventional Dendritic Cells Controls Cutaneous Bacterial Infections through VEGFα-Mediated Recruitment of Neutrophils
Janela B, Patel AA, Lau MC, Goh CC, Msallam R, Kong WT, Fehlings M, Hubert S, Lum J, Simoni Y, Malleret B, Zolezzi F, Chen J, Poidinger M, Satpathy AT, Briseno C, Wohn C, Malissen B, Murphy KM, Maini AA, Vanhoutte L, Guilliams M, Vial E, Hennequin L, Newell E, Ng LG, Musette P, Yona S, Hacini-Rachinel F, Ginhoux F.
Immunity, 16 April 2019
Interrogation of human hematopoiesis at single-cell and single-variant resolution
Ulirsch JC*, Lareau CA*, Bao EL*, Ludwig LS, Guo MH, Benner C, Satpathy AT, Salem R, Hirschhorn JN, Finucane HK, Aryee MJ, Buenrostro JD*, Sankaran VG*.
Nature Genetics, 11 March 2019