Massively parallel single-cell chromatin landscapes of human immune cell development and intratumoral T cell exhaustion

Satpathy AT*, Granja JM*, Yost KE, Qi Y, Meschi F, McDermott GP, Olsen BN, Mumbach MR, Pierce SE, Corces MR, Shah P, Bell JC, Jhutty D, Nemec CM, Wang J, Wang L, Yin Y, Giresi PG, Chang ALS, Zheng GXY*, Greenleaf WJ*, Chang HY*. *contributed equally
Nature Biotechnology, 2 August 2019

Clonal replacement of tumor-specific T cells following PD-1 blockade

Yost KE*, Satpathy AT*, Wells DK, Qi Y, Wang C, Kageyama R, McNamara K, Granja JM, Sarin KY, Brown RA, Gupta RK, Curtis C, Bucktrout SL, Davis MM, Chang ALS*, Chang HY*. *contributed equally
Nature Medicine, 29 July 2019

HiChIRP reveals RNA-associated chromosome conformation

Mumbach MR*, Granja JG*, Flynn RA, Roake CM, Satpathy AT, Rubin AJ, Qi Y, Jiang Z, Shams S, Louie BH, Guo JK, Gennert DG, Corces MR, Khavari PA, Atianand MK, Artandi SE, Fitzgerald KA, Greenleaf WJ*, Chang HY*.
Nature Methods, 27 May 2019

A Subset of Type I Conventional Dendritic Cells Controls Cutaneous Bacterial Infections through VEGFα-Mediated Recruitment of Neutrophils

Janela B, Patel AA, Lau MC, Goh CC, Msallam R, Kong WT, Fehlings M, Hubert S, Lum J, Simoni Y, Malleret B, Zolezzi F, Chen J, Poidinger M, Satpathy AT, Briseno C, Wohn C, Malissen B, Murphy KM, Maini AA, Vanhoutte L, Guilliams M, Vial E, Hennequin L, Newell E, Ng LG, Musette P, Yona S, Hacini-Rachinel F, Ginhoux F.
Immunity, 16 April 2019

Interrogation of human hematopoiesis at single-cell and single-variant resolution

Ulirsch JC*, Lareau CA*, Bao EL*, Ludwig LS, Guo MH, Benner C, Satpathy AT, Salem R, Hirschhorn JN, Finucane HK, Aryee MJ, Buenrostro JD*, Sankaran VG*.
Nature Genetics, 11 March 2019

A mutation in the transcription factor Foxp3 drives T helper 2 effector function in regulatory T cells

Van Gool F, Nguyen MLT, Mumbach MR, Satpathy AT, Rosenthal WL, Giacometti S, Le DT, Liu W, Brusko TM, Anderson MS, Rudensky AY, Marson A, Chang HY, Bluestone JA.
Immunity, 19 February 2019

Pembrolizumab for advanced basal cell carcinoma: an investigator-initiated, proof-of-concept study

Chang ALS, Tran DC, Cannon JGD, Li S, Jeng M, Patel R, Van der Bokke L, Pague A, Brotherton R, Rieger KE, Satpathy AT, Yost KE, Reddy S, Sarin K, Colevas AD.
Journal of the American Academy of Dermatology, 1 February 2019

Coupled single-cell CRISPR screening and epigenomic profiling reveals causal gene regulatory networks

Rubin AJ*, Parker KR*, Satpathy AT*, Qi Y, Wu B, Ong AJ, Mumbach MR, Ji AL, Kim DS, Cho SW, Zarnegar BJ, Greenleaf WJ, Chang HY*, Khavari PA*.
Cell, 10 January 2019

The chromatin accessibility landscape of primary human cancers

Corces MR*, Granja JM*, Shams S, Louie BH, Seoane JA, Zhou W, Silva TC, Greoneveld C, Wong CK, Cho SW, Satpathy AT, Mumbach MR, Hoadley KA, Robertson AG, Sheffield NC, Felau I, Castro MAA, Berman BP, Staudt LM, Zenklusen JC, Laird PW, Curtis C, TCGA, Greenleaf WJ*, Chang HY*.
Science, 26 October 2018

Notch2-dependent DC2s mediate splenic germinal center responses

Briseno CG, Satpathy AT, Davidson JT, Ferris ST, Dura V, Bagadia P, O’Connor KW, Theisen DJ, Murphy TL, Murphy KM.
PNAS, 16 October 2018