The temporal progression of lung immune remodeling during breast cancer metastasis
Christopher S McGinnis, Zhuang Miao, Daphne Superville, Winnie Yao, Andrei Goga, Nathan E Reticker-Flynn, Juliane Winkler, Ansuman T Satpathy
Cancer Cell, 10 June 2024
Systematic decoding of cis gene regulation defines context-dependent control of the multi-gene costimulatory receptor locus in human T cells
Cody T Mowery, Jacob W Freimer, Zeyu Chen, Salvador Casaní-Galdón, Jennifer M Umhoefer, Maya M Arce, Ketrin Gjoni, Bence Daniel, Katalin Sandor, Benjamin G Gowen, Vinh Nguyen, Dimitre R Simeonov, Christian M Garrido, Gemma L Curie, Ralf Schmidt, Zachary Steinhart, Ansuman T Satpathy, Katherine S Pollard, Jacob E Corn, Bradley E Bernstein, Chun Jimmie Ye, Alexander Marson
Nature Genetics, 29 May 2024
Direct transposition of native DNA for sensitive multimodal single-molecule sequencing
Arjun S Nanda, Ke Wu, Iryna Irkliyenko, Brian Woo, Megan S Ostrowski, Andrew S Clugston, Leanne C Sayles, Lingru Xu, Ansuman T Satpathy, Hao G Nguyen, E Alejandro Sweet-Cordero, Hani Goodarzi, Sivakanthan Kasinathan, Vijay Ramani
Nature Genetics, 9 May 2024
FOXO1 is a master regulator of memory programming in CAR T cells
Alexander E Doan, Katherine P Mueller, Andy Y Chen, Geoffrey T Rouin, Yingshi Chen, Bence Daniel, John Lattin, Martina Markovska, Brett Mozarsky, Jose Arias-Umana, Robert Hapke, In-Young Jung, Alice Wang, Peng Xu, Dorota Klysz, Gabrielle Zuern, Malek Bashti, Patrick J Quinn, Zhuang Miao, Katalin Sandor, Wenxi Zhang, Gregory M Chen, Faith Ryu, Meghan Logun, Junior Hall, Kai Tan, Stephan A Grupp, Susan E McClory, Caleb A Lareau, Joseph A Fraietta, Elena Sotillo, Ansuman T Satpathy, Crystal L Mackall, Evan W Weber
Nature, 10 April 2024
Inosine induces stemness features in CAR-T cells and enhances potency
Dorota D Klysz, Carley Fowler, Meena Malipatlolla, Lucille Stuani, Katherine A Freitas, Yiyun Chen, Stefanie Meier, Bence Daniel, Katalin Sandor, Peng Xu, Jing Huang, Louai Labanieh, Vimal Keerthi, Amaury Leruste, Malek Bashti, Janette Mata-Alcazar, Nikolaos Gkitsas, Justin A Guerrero, Chris Fisher, Sunny Patel, Kyle Asano, Shabnum Patel, Kara L Davis, Ansuman T Satpathy, Steven A Feldman, Elena Sotillo, Crystal L Mackall
Cancer Cell, 12 February 2024
Latent human herpesvirus 6 is reactivated in CAR T cells
Caleb A Lareau, Yajie Yin, Katie Maurer, Katalin D Sandor, Bence Daniel, Garima Yagnik, José Peña, Jeremy Chase Crawford, Anne M Spanjaart, Jacob C Gutierrez, Nicholas J Haradhvala, Janice M Riberdy, Tsion Abay, Robert R Stickels, Jeffrey M Verboon, Vincent Liu, Frank A Buquicchio, Fangyi Wang, Jackson Southard, Ren Song, Wenjing Li, Aastha Shrestha, Laxmi Parida, Gad Getz, Marcela V Maus, Shuqiang Li, Alison Moore, Zachary J Roberts, Leif S Ludwig, Aimee C Talleur, Paul G Thomas, Houman Dehghani, Thomas Pertel, Anshul Kundaje, Stephen Gottschalk, Theodore L Roth, Marie J Kersten, Catherine J Wu, Robbie G Majzner, Ansuman T Satpathy
Nature, 8 November 2023
Mitigation of chromosome loss in clinical CRISPR-Cas9-engineered T cells
Connor A Tsuchida, Nadav Brandes, Raymund Bueno, Marena Trinidad, Thomas Mazumder, Bingfei Yu, Byungjin Hwang, Christopher Chang, Jamin Liu, Yang Sun, Caitlin R Hopkins, Kevin R Parker, Yanyan Qi, Laura Hofman, Ansuman T Satpathy, Edward A Stadtmauer, Jamie H D Cate, Justin Eyquem, Joseph A Fraietta, Carl H June, Howard Y Chang, Chun Jimmie Ye, Jennifer A Doudna
Cell, 12 October 2023
Modular pooled discovery of synthetic knockin sequences to program durable cell therapies
Franziska Blaeschke, Yan Yi Chen, Ryan Apathy, Bence Daniel, Andy Y. Chen, Peixin Amy Chen,
Katalin Sandor, Wenxi Zhang, Zhongmei Li, Cody T. Mowery, Tori N. Yamamoto, William A. Nyberg,
Angela To, Ruby Yu, Raymund Bueno, Min Cheol Kim, Ralf Schmidt, Daniel B. Goodman,
Tobias Feuchtinger, Justin Eyquem, Chun Jimmie Ye, Julia Carnevale,
Ansuman T. Satpathy, Eric Shifrut, Theodore L. Roth, and Alexander Marson
Cell, 14 September 2023
Single-cell multi-omics of mitochondrial DNA disorders reveals dynamics of purifying selection across human immune cells
Caleb A. Lareau, Sonia M. Dubois, Frank A. Buquicchio, Yu-Hsin Hsieh, Kopal Garg, Pauline Kautz, Lena Nitsch, Samantha D. Praktiknjo, Patrick Maschmeyer, Jeffrey M. Verboon, Jacob C. Gutierrez, Yajie Yin, Evgenij Fiskin, Wendy Luo, Eleni P. Mimitou, Christoph Muus, Rhea Malhotra, Sumit Parikh, Mark D. Fleming, Lena Oevermann, Johannes Schulte, Cornelia Eckert, Anshul Kundaje, Peter Smibert, Santosha A. Vardhana, Ansuman T. Satpathy, Aviv Regev, Vijay G. Sankaran, Suneet Agarwal & Leif S. Ludwig
Nature Genetics, 29 June 2023
Clonal hematopoiesis is associated with protection from Alzheimer’s disease
Hind Bouzid, Julia A. Belk, Max Jan, Yanyan Qi, Chloé Sarnowski, Sara Wirth, Lisa Ma, Matthew R. Chrostek, Herra Ahmad, Daniel Nachun, Winnie Yao, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Alexa Beiser, Alexander G. Bick, Joshua C. Bis, Myriam Fornage, William T. Longstreth Jr., Oscar L. Lopez, Pradeep Natarajan, Bruce M. Psaty, Claudia L. Satizabal, Joshua Weinstock, Eric B. Larson, Paul K. Crane, C. Dirk Keene, Sudha Seshadri, Ansuman T. Satpathy, Thomas J. Montine & Siddhartha Jaiswal
Nature Medicine, 15 June 2023